Oral soft tissue wound healing following the application of an oxygen-releasing gel

a case series

Resumen

Oral soft tissue healing represents a clinical challenge due to continuous exposure to saliva, mechanical stress, and a complex microbial environment that may impair tissue repair. Novel therapeutic approaches aimed at optimizing local oxygen availability have emerged as promising adjuncts in wound management. This manuscript aims to evaluate the clinical outcomes of oral soft tissue wound healing following the topical application of an oxygen-releasing gel in different clinical scenarios involving oral mucosal injury. Patients presenting with oral soft tissue wounds of distinct etiologies were treated with a topical oxygen-releasing gel as an adjunctive therapy. The gel releases active oxygen upon contact with saliva, promoting angiogenesis and creating a favorable microenvironment for tissue regeneration while limiting anaerobic bacterial proliferation. Clinical healing outcomes were assessed based on tissue repair progression and postoperative recovery. Favorable healing responses were observed across all cases, with accelerated epithelialization, reduced inflammatory signs, and uneventful healing patterns. Based on the findings of this case series, we can conclude that the topical application of an oxygen-releasing gel showed promising clinical outcomes as an adjunctive approach for oral soft tissue wound management. Oxygen-delivering hydrogels may represent a biologically compatible and effective strategy to enhance tissue repair in oral clinical practice.